(g)kenney lab publications
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‡Authors contributed equally to the manuscript. §Corresponding author. ¶Publication of particular interest
24. J.A. Velilla, G.E. Kenney, R. Gaudet§. Structure and function of prodrug-activating peptidases. Biochimie. 205:124-135. (2023) DOI: 10.1016/j.biochi.2022.07.019
23. J.A. Velilla, M.R. Volpe, G.E. Kenney, R.M. Walsh Jr., E.P. Balskus, R. Gaudet§. Structural basis of colibactin activation by the ClbP peptidase. Nat. Chem. Biol. 19:151-158 (2023) DOI: 10.1038/s41589-022-01142-z
22. L.F. Schachner, B. Des Soye, S.Y. Ro, G.E. Kenney, A. Ives, T. Su, Y.A. Goo, M. Jewett, A.C. Rosenzweig, N.L. Kelleher§. Revving an engine of human metabolism: activity enhancement of triosephosphate isomerase via hemi-phosphorylation. 17:2769-2780. ACS Chem. Biol. (2022) DOI: 10.1021/acschembio.2c00324
21. Y.J. Park, G.M. Roberts, R. Montaser, G.E. Kenney, P.M. Thomas, N.L Kelleher, A.C. Rosenzweig§. Characterization of a copper-chelating natural product from the methanotroph Methylosinus sp. LW3. Biochemistry. 60:2845-2850 (2021) DOI: 10.1021/acs.biochem.1c00443
20. J.C.-C. Chou, V.E. Stafford, G.E. Kenney§, L.M.K. Dassama§. The enzymology of oxazolone and thioamide synthesis in methanobactin. Methods Enzymol. 656:341-373 (2021) DOI: 10.1016/bs.mie.2021.04.008
19. M. McBride, D. Sil, T.L. Ng, A.M. Crooke, G.E. Kenney, C.R. Tysoe, B. Zhang, E.P. Balskus, A.K. Boal, C. Krebs, J.M. Bollinger§. A peroxodiiron (III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozoticin by SznF. J. Am. Chem. Soc. 142:11818-11828. (2020) DOI: 10.1021/jacs.0c03431
18. J.E. Bisanz, P. Soto-Perez, C. Noecker, A.A. Aksenov, K.N. Lam, G.E. Kenney, E.N. Bess, H.J. Haiser, T.S. Kyaw, F.B. Yu, V.M. Rekdal, C.W.Y. Ha, S. Devkota, E.P Balskus, P.C. Dorrestein, E. Allen-Vercoe, P.J. Turnbaugh§. A genomic toolkit for the mechanistic dissection of intractable human gut bacteria. Cell Host Microbe. 1001-1013. (2020) DOI: 10.1016/j.chom.2020.04.006
17.¶ G.E. Kenney‡, L.M.K. Dassama‡, A.C. Manesis, M.O. Ross, S. Chen, B.M. Hoffman, and A.C. Rosenzweig§. MbnH is a diheme MauG-like protein associated with microbial copper homeostasis. J. Biol. Chem. 294:16141-16151. (2019) DOI: 10.1074/jbc.ra119.010202
16. S.Y. Ro‡, L.F. Schachner‡, C.W. Koo, R. Purohit, J.P. Remis, G.E. Kenney, B.W. Liauw, P.M. Thomas, N.L. Kelleher, and A.C. Rosenzweig§. Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase. Nat. Commun. 10:2675. (2019) DOI: 10.1038/s41467-019-10590-6
15. O.S. Fisher, G.E. Kenney, M.O. Ross, S.Y. Ro, B. Lemma, S. Batelu, P.M. Thomas, V.C. Sosnowski, C.J. DeHart, N.L. Kelleher, T.L. Stemmler, B.M. Hoffman, A.C. Rosenzweig§. Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria. Nat. Commun. 9:4276. (2018) DOI: 10.1038/s41467-018-06681-5
14. Y.J. Park‡, G.E. Kenney‡, L.F. Schachner, N.L. Kelleher and A.C. Rosenzweig§. Repurposed HisC aminotransferases complete the biosynthesis of some methanobactins. Biochemistry. 57:3515-3523. (2018) DOI: 10.1021/acs.biochem.8b00296
13. G.E. Kenney§, A.C. Rosenzweig§. Chalkophores. Annu. Rev. Biochem. 87:645-676. (2018) DOI: 10.1146/annurev-biochem-062917-012300
12.¶ G.E. Kenney, L.M.K. Dassama, M.-E. Pandelia, A.S. Gizzi, R.J. Martinie, P. Gao, C.J. DeHart, L.F. Schachner, O.S. Skinner, X. Zhu, M. Sadek, P.M. Thomas, S.C. Almo, J.M. Bollinger, C. Krebs, N.L. Kelleher, A.C. Rosenzweig§. The biosynthesis of methanobactin. Science. 359:1411-1416. (2018) DOI: 10.1126/science.aap9437
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11. G.E. Kenney and A.C. Rosenzweig§. Methanobactins: maintaining copper homeostasis in methanotrophs and beyond. J. Biol. Chem. 293:4606-4615. (2018) DOI: 10.1074/jbc.tm117.000185
10. L.M.K. Dassama‡, G.E. Kenney‡, A.C. Rosenzweig§. Methanobactins: from genome to function. Metallomics. 9: 7-20. (2017) DOI: 10.1039/c6mt00208k
9. L.M.K. Dassama, G.E. Kenney, S.Y. Ro, E.L. Zielazinski, A.C. Rosenzweig§. Methanobactin transport machinery. Proc. Nat. Acad. Sci. 113:13027-13032. (2016) DOI: 10.1073/pnas.1603578113
8.¶ G.E. Kenney, A.W. Goering, M.O. Ross, C.J. DeHart, P.M. Thomas, B.M. Hoffman, N.L. Kelleher, A.C. Rosenzweig§. Characterization of methanobactin from Methylosinus sp. LW4. J. Am. Chem. Soc. 138:11124-11127. (2016) DOI: 10.1021/jacs.6b06821
7. T.J. Lawton, G.E. Kenney, J.D. Hurley, A.C. Rosenzweig§. The growing CopC family: Structural and bioinformatic insights into a diverse group of copper chaperones. Biochemistry. 55:2278-2290. (2016) DOI: 10.1021/acs.biochem.6b00175
6.¶ G.E. Kenney, M. Sadek, A.C. Rosenzweig§. Copper-responsive gene expression in the methanotroph Methylosinus trichosporium OB3b. Metallomics. 8:931-940. (2016) DOI: 10.1039/c5mt00289c
5. R.N. Austin, G.E. Kenney, A.C. Rosenzweig§. Perspective: what is known, and not known, about the connections between alkane oxidation and metal uptake in alkanotrophs in the marine environment. Metallomics. 6:1121-1125. (2014) DOI: 10.1039/c4mt00041b
4. G.E. Kenney, A.C. Rosenzweig§. Chemistry and biology of the copper chelator methanobactin. ACS Chem. Biol. 7:260-268. (2012) DOI: 10.1021/cb2003913
3.¶ G.E. Kenney, A.C. Rosenzweig§. Genome mining for methanobactins. BMC Biol. 11:17. (2013) DOI: 10.1186/1741-7007-11-17
2. R. Balasubramanian, G.E. Kenney, A.C. Rosenzweig§. Dual pathways for copper uptake in methanotrophic bacteria. J. Biol. Chem. 286:37313–37319. (2011) DOI: 10.1074/jbc.m111.284984
1. J. Chen, M. Ghorai, G.E. Kenney, J. Stubbe§. Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage. Nucl. Acids. Res. 36:3781-3790. (2008) DOI: /10.1093/nar/gkn302